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抗癫痫药被列为必需监测的药物,在发达的国家已是一项常规测定,本院于1986～1987年先后建立了丙戊酸、苯巴比妥、苯妥英、朴痫酮和卡马西平等5种抗癫药的血药浓度测定方法,丙戊酸以气相色谱法,其它均以高效液相色谱法测定。方法的线性范围、准确度和精密度均符合临床要求。两年来对364人次作了597次测定,数据作了以下分析:①以各药物的有效治疗浓度范围为标准,分析我院癫痫就诊患者在常规给药时血药浓度的分布情况,结果表明这5种药物达到有效治疗浓度范围的占20％～63％,其中苯妥
Antiepileptic drugs are listed as essential drugs for monitoring, which is already a routine measure in developed countries. The hospital established valproate, phenobarbital, phenytoin, Equal five kinds of antiepileptic drug concentration determination method, valproic acid by gas chromatography, others were determined by high performance liquid chromatography. The linear range, accuracy and precision of the method are in line with clinical requirements. In the past two years, we made 597 determinations on 364 people. The data were analyzed as follows: ①According to the effective treatment concentration range of each drug, we analyzed the distribution of plasma concentration in patients with epilepsy in our hospital during routine administration. 5 kinds of drugs to achieve an effective therapeutic concentration range of 20% to 63%, of which phenytoin