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目的:探讨新辅助化疗子宫动脉置管与静脉全身化疗不同给药途径对局部晚期宫颈癌患者血管内皮生长因子(vascular endothelial growth factor,VEGF)mRNA表达的影响及其临床意义。方法:应用实时定量PCR方法检测43例局部晚期宫颈癌患者子宫动脉置管(观察组23例)与静脉全身化疗(对照组20例)后癌组织的VEGF mRNA表达,评定化疗近期效果。结果:2种方法治疗晚期宫颈癌临床缓解率相似,子宫动脉置管可明显减少化疗引起骨髓抑制和肝功能损害,化疗后宫颈癌组织VEGF mRNA表达较静脉全身化疗明显降低(P<0.05)。结论:术前子宫动脉置管化疗可降低宫颈癌组织VEGF mRNA的表达,减少化疗不良反应。
OBJECTIVE: To investigate the effects of neoadjuvant chemotherapy with different routes of administration of uterine artery and intravenous systemic chemotherapy on the expression of vascular endothelial growth factor (VEGF) mRNA in locally advanced cervical cancer and its clinical significance. Methods: Real-time quantitative PCR was used to detect the expression of VEGF mRNA in 43 patients with locally advanced cervical cancer who underwent uterine arterial catheterization (observation group, 23 cases) and intravenous systemic chemotherapy (20 cases, control group), and to evaluate the recent effect of chemotherapy. Results: The two methods of treatment of advanced cervical cancer clinical remission rate similar, uterine artery catheterization can significantly reduce chemotherapy-induced bone marrow suppression and liver dysfunction after chemotherapy, VEGF mRNA expression in cervical cancer tissue was significantly lower than intravenous systemic chemotherapy (P <0.05). Conclusion: Preoperative uterine artery catheterization chemotherapy can reduce the expression of VEGF mRNA in cervical cancer tissue and reduce the adverse reaction of chemotherapy.