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本文作者介绍一种对阈剂量或阈下剂量作机率评价的简便方法,主要依据效应与剂量的可信限范围存在着相互关系的原则。具体介绍了图解法和计算法。上述评价方法是以被试物质效应强度(E)与剂量(D)对数呈正比为前提条件。为了检验这个方法的可靠性,在同一实验内作用剂量组不得少于3个,各剂量组作用结果应与对照组有显著的差异。同时,要计算每一作用剂量的平均值及可信限范围。其详细评价如下:
The authors present a simple method for assessing the probability of threshold or subthreshold dose based on the principle of reciprocity between the effects and the credible limits of dose. Specific introduction of graphic method and calculation method. The evaluation method is based on the test substance intensity (E) and the dose (D) logarithmically proportional to the premise. In order to test the reliability of this method, in the same experiment dose group of not less than 3, the effect of each dose group results should be significantly different from the control group. At the same time, calculate the average of each dose and the range of confidence limits. Its detailed evaluation is as follows: