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为探讨胰岛素样生长因子在生长迟缓诊断中的意义，我们用免疫放射计量（ＩＲＭＡ）方法以及放射免疫（ＲＩＡ）方法测定身材矮小患儿２２例药物激发试验和１９３例运动激发试验血清中ＩＧＦ－１、ＩＧＦＢＰ－３和ＧＨ水平。结果：①正常对照组ＩＧＦ－１水平在不同年龄不同性别间有显著意义（Ｐ＜００１）ＩＧＦＢＰ－３水平在各年龄组之间差异无显著性意义。②ＧＨＤ组病人ＧＨ、ＩＧＦ－１、ＩＧＦＢＰ－３水平均是降低的。结论：ＩＧＦ－１和ＩＧＦＢＰ－３水平可以反映体内ＧＨ的分泌情况。
To investigate the significance of insulin-like growth factor (IGF-I) in the diagnosis of growth retardation, we measured the serum levels of IGF-1 and IGF-1 in 22 patients with short stature and 23 patients with exercise-induced test by radioimmunoassay (IRMA) and radioimmunoassay 1, IGFBP-3 and GH levels. Results: ① The level of IGF-1 in the normal control group was significantly different between different sexes (P <001). There was no significant difference in IGFBP-3 among all age groups. ②GHD patients GH, IGF-1, IGFBP-3 levels were reduced. Conclusion: IGF-1 and IGFBP-3 levels can reflect the secretion of GH in vivo.