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血管紧张素转换酶抑制剂(ACEI)已被应用于心肌梗死伴左心室(LV)功能不全的患者,但ACEI对LV功能正常患者的治疗作用尚未开展广泛研究。福辛普利治疗急性心肌梗死研究(FAMIS)旨在观察前壁心肌梗死患者行静脉溶栓治疗后早期使用ACEI对LV扩张进展和临床预后的长期效应。
Angiotensin converting enzyme inhibitors (ACEI) have been used in patients with myocardial infarction and left ventricular (LV) insufficiency. However, extensive studies have not been done on the therapeutic effect of ACEI on patients with normal LV function. The Fosinopril Treatment of Acute Myocardial Infarction Study (FAMIS) aims to investigate the long-term effects of early use of ACEI on progression of LV dilatation and clinical outcome after an intravenous thrombolytic therapy in patients with anterior myocardial infarction.