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以中西医结合组(抗心梗煎剂加西药)和对照组(单纯西药)分3个阶段对60例急性心肌梗塞(AMI)患者治疗前后的临床表现、合并症、抢救成功率、心电图ST段、心肌酶谱、血液流变学、体外血栓形成及血清中超氧化物歧化酶(SOD)和脂质过氧化产物丙二醛(MDA)做对比观察,60例AMI患者与30例健康人SOD及MDA对照。结果显示,AMI患者与健康人SOD及MDA有明显差异。经治疗后10d及30d中西医结合组与对照组上述各项观察指标均有明显差异。显示中西医结合组中的抗心梗煎剂(Ⅰ号、Ⅱ号)明显改善AMI患者超急性期及急性期血氧供需平衡、缩小心梗面积,改善临床症状及心功能,减少恶性心律失常及早期死亡率,同时显示中西医结合组在AMI治疗中显著的抗脂质过氧化及清除自由基的作用,亦有明显改善血液粘滞度及抗血栓功效。对抗心梗煎剂的作用机理作了较深入的探讨。
To 60 cases of acute myocardial infarction (AMI) patients with clinical manifestations, complications, rescue success rate, ECG ST , Myocardial enzymes, hemorheology, thrombosis in vitro and serum superoxide dismutase (SOD) and lipid peroxidation product malondialdehyde (MDA) were compared between 60 AMI patients and 30 healthy people SOD And MDA control. The results showed that AMI patients and healthy people SOD and MDA were significantly different. After treatment 10d and 30d Integrative Medicine Group and the control group of the above indicators were significantly different. Anti-heart decoction decoction (Ⅰ, Ⅱ) in Integrative Medicine group significantly improved the balance between supply and demand of hyperacute-phase and acute-phase AMI in AMI patients, reduced myocardial infarct size, improved clinical symptoms and cardiac function, reduced malignant arrhythmia And early mortality, at the same time showed Integrative Medicine group AMI treatment in the significant anti-lipid peroxidation and scavenging free radicals, but also significantly improved blood viscosity and anti-thrombotic effect. Against myocardial infarction decoction mechanism made a more in-depth discussion.