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采用在家兔全麻、开胸、自主呼吸和自主心律的条件下,结扎冠状动脉左室支造成急性心肌缺血模型,进而松开结扎结形成再灌注损伤模型。观察丹参对心肌缺血和再灌注损伤的组织脂质过氧化物含量和局部血流量变化的影响,结果表明:①心肌缺血和再灌注损伤形成时,组织脂质过氧化物含量显著增高;丹参能有效地抑制脂质过氧化物的形成。②长时间(60分钟)缺血后再灌注可见无复流现象存在于缺血区,丹参通过增加再灌注缺血区的局部血流量恢复防止了无复流的出现。
Under conditions of rabbit general anesthesia, thoracotomy, spontaneous breathing, and spontaneous rhythm, the left ventricular branch of the coronary artery was ligated to cause acute myocardial ischemia, and then the ligation knot was released to form a reperfusion injury model. Observing the effects of Salvia miltiorrhiza on myocardial lipid peroxidation and local blood flow in myocardial ischemia and reperfusion injury, the results showed that: 1 When the myocardial ischemia and reperfusion injury were formed, the content of lipid peroxides increased significantly. Salvia miltiorrhiza can effectively inhibit the formation of lipid peroxides. 2 Long-term (60 minutes) ischemia-reperfusion showed that no reflow phenomenon exists in the ischemic area. Salvia miltiorrhiza can prevent the no-reflow phenomenon by increasing the local blood flow recovery in the ischemic region.