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许多临床现象观察到放疗后使用阿霉素(ADR)或放线菌素D(ACT-D)出现一些严重的正常组织并发症,称之为“再现现象”。作者利用小鼠胸部照射后不同时间给予ADR或ACT-D,研究放疗和化疗时间间隔对放射性肺炎及脱发的影响,以及放疗剂量大小的重要性。10～12周龄C_3Hf/Sed//Kam SPF小鼠,~(137)Cs源胸部照射,剂量率1Gy/min,剂量范围6.0～15.3Gy。ADR1.2mg/kg、ACT-D0.6mg/kg尾静脉注射,一周内给2次,每次一半剂量,对照组证明此浓度对小鼠存活无影响。分别在照射后12～16小时(0M组)、1个月(1M组)、2个月(2M组)、3个月(3M组)给药。160天后计算LD_(50)和MST(中位生存时间),98天后每周1～2次观察射野区毛发反应,划分脱发等级,结果与单独照射组比较。
Many clinical phenomena have observed some serious normal tissue complications after administration of adriamycin (ADR) or actinomycin D (ACT-D) after radiotherapy, which is referred to as “reproducing phenomenon”. The authors used ADR or ACT-D at different times after irradiation on the mouse’s chest to study the effect of radiotherapy and chemotherapy intervals on radiation pneumonitis and hair loss, and the importance of radiotherapy dose size. C_3Hf/Sed//Kam SPF mice aged 10 to 12 weeks were radiated with ~(137)Cs, with a dose rate of 1 Gy/min and a dose range of 6.0 to 15.3 Gy. ADR1.2mg/kg, ACT-D0.6mg/kg tail vein injection, two times a week, each half dose, the control group proved that this concentration has no effect on the survival of mice. They were administered 12 to 16 hours (0M group), 1 month (1M group), 2 months (2M group), and 3 months (3M group) after irradiation. The LD 50 and MST were calculated 160 days later. The hairy area hair reaction was observed 1 or 2 times a week 98 days later. Hair loss was graded. The results were compared with those of the irradiated group alone.