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目的探讨慢性心力衰竭(CHF)患者血清MMP-9、超敏C反应蛋白(hs-CRP)、血尿酸(UA)变化以及相关性。方法入选98例慢性心力衰竭患者和21例健康体检者作为正常对照组,采用免疫透射比浊法测hs-CRP;酶联免疫吸附法测血清MMP-9;氧化酶法测UA;彩色多普勒超声心动图进行左室参数的测定。结果 CHF患者血清MMP-9、hs-CRP、UA水平较对照组明显升高(P<0.01)。不同心功能分级的CHF患者MMP-9、hs-CRP及UA水平较对照组升高(P<0.01或<0.05);心功能越差,MMP-9、hs-CRP及UA水平越高,左室舒末内径越大,左室射血分数越低,组间差异有统计学意义(P<0.05)。不同病因相同心功能分级的CHF患者血清MMP-9、hs-CRP、UA水平差异无统计学意义(P>0.05)。CHF患者血清MMP-9、hs-CRP、尿酸水平与LVEF有较好的相关性,且与NYHA分级正相关;血清MMP-9与hs-CRP、LVEED亦有较好的相关性。结论血清MMP-9、hs-CRP、UA的浓度对判断慢性心力衰竭患者病情严重程度及预后有重要意义。
Objective To investigate the changes of serum MMP-9, hs-CRP and UA in patients with chronic heart failure (CHF). Methods Ninety-eight patients with chronic heart failure and 21 healthy subjects were enrolled as normal control group, hs-CRP was measured by immunoturbidimetry, serum MMP-9 was measured by enzyme-linked immunosorbent assay, UA was detected by oxidase method, Left ventricular parameters were measured by echocardiography. Results The serum levels of MMP-9, hs-CRP and UA in CHF patients were significantly higher than those in control group (P <0.01). The levels of MMP-9, hs-CRP and UA in CHF patients with different cardiac function were significantly higher than those in control group (P <0.01 or <0.05). The worsened cardiac function was, the higher the levels of MMP-9, hs- The larger the end-diastolic diameter, the lower the left ventricular ejection fraction, the difference between the two groups was statistically significant (P <0.05). The serum levels of MMP-9, hs-CRP and UA in CHF patients with different etiology and cardiac function were not significantly different (P> 0.05). The serum levels of MMP-9, hs-CRP and uric acid in patients with CHF were positively correlated with LVEF, and positively correlated with NYHA classification. There was also a good correlation between serum MMP-9 and hs-CRP and LVEED. Conclusions Serum levels of MMP-9, hs-CRP and UA are of great importance in judging the severity and prognosis of patients with chronic heart failure.