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目的观察临床心绞痛(AP)病人血清脂联素水平的变化,并探讨其临床意义。方法选取AP病人62例,其中稳定型心绞痛(SAP)25例,不稳定型心绞痛(UAP)37例,以正常健康人28例为正常对照组。所有研究对象均测定血压、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高敏C-反应蛋白(hs-CRP)和血清脂联素水平。结果 AP患者的血压、TG、TC、LDL-C、hs-CRP和血清脂联素水平均较正常对照组明显升高(P<0.05)。UAP组和SAP组对比,血压、TG、TC、LDL-C差异无统计学意义,但是UAP组患者的hs-CRP和血清脂联素水平明显高于SAP组(P<0.05)。AP患者的脂联素与hs-CRP水平有良好的正相关性(r=0.331,P<0.05)。结论脂联素在AP的发病中起着重要的作用,可以作为临床AP严重程度的重要实验室指标。
Objective To observe the changes of serum adiponectin levels in patients with clinical angina pectoris (AP) and to explore its clinical significance. Methods Totally 62 AP patients were selected, including 25 cases of stable angina pectoris (SAP) and 37 cases of unstable angina pectoris (UAP), and 28 cases of normal healthy people as normal control group. All subjects measured blood pressure, triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high-sensitivity C-reactive protein (hs-CRP) and serum adiponectin levels. Results The levels of blood pressure, TG, TC, LDL-C, hs-CRP and serum adiponectin in AP patients were significantly higher than those in normal controls (P <0.05). There were no significant differences in blood pressure, TG, TC and LDL-C between UAP group and SAP group. However, the levels of hs-CRP and serum adiponectin in UAP group were significantly higher than those in SAP group (P <0.05). There was a good positive correlation between adiponectin and hs-CRP in patients with AP (r = 0.331, P <0.05). Conclusion Adiponectin plays an important role in the pathogenesis of AP and may serve as an important laboratory index for the severity of clinical AP.