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目的观察高敏C反应蛋白(hs-CRP),纤维蛋白原(Fbg)和D-二聚体在老年COPD患者中的临床意义。方法选择2009年1月～2010年12月就诊的老年COPD患者90例,其中缓解期22例,急性加重期68例。选择同期健康体检的志愿者15例。分别检测患者及健康志愿者的血清hs-CRP,Fbg和D-二聚体的水平。结果急性加重期和缓解期COPD患者的血清hs-CRP、Fbg和D-二聚体水平较对照组明显增高,而急性加重期的血清hs-CRP、Fbg和D-二聚体水平较缓解期明显增高,差异有统计学意义(P<0.01)。随着肺功能分级的升高血清hs-CRP、Fbg和D-二聚体水平也逐步升高,差异有统计学意义(P<0.01)。结论 hs-CRP、Fbg和D-二聚体参与了COPD的发病过程,对其检测有助于对病情的判断。
Objective To observe the clinical significance of high sensitivity C-reactive protein (hs-CRP), fibrinogen (Fbg) and D-dimer in elderly patients with COPD. Methods 90 elderly COPD patients were selected from January 2009 to December 2010, of which 22 were in remission and 68 in acute exacerbation. Select the same period of physical examination of 15 volunteers. Serum levels of hs-CRP, Fbg and D-dimer were measured in patients and healthy volunteers, respectively. Results Serum levels of hs-CRP, Fbg and D-dimer in COPD patients were significantly higher than those in control group in acute exacerbation and remission stages, but serum levels of hs-CRP, Fbg and D-dimer in acute exacerbation were significantly higher than those in remission Was significantly higher, the difference was statistically significant (P <0.01). The levels of hs-CRP, Fbg and D-dimer also increased gradually with the increase of pulmonary function grade, the difference was statistically significant (P <0.01). Conclusion hs-CRP, Fbg and D-dimer are involved in the pathogenesis of COPD, and its detection can be helpful to judge the condition.