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静电纺丝仿生天然细胞外基质(ECM)结构,所制备的高度多孔、高比表面积的纳米级(50～500nm)纤维赋予了丰富的分子架构和生化信号,为种子细胞提供理想的生长微环境.不同组分、纤维尺寸及取向和种子细胞类型,可以裁剪获得不同生化和力学性能的电纺支架细胞复合物.总结了血管组织工程仿生ECM的设计与构建,并强调与支架复合的种子细胞在血管组织工程的作用.
The electrospinning biomimetic natural extracellular matrix (ECM) structure, prepared by the highly porous, high specific surface area of nanoscale (50 ~ 500nm) fibers to give a rich molecular structure and biochemical signals for the seed cells to provide the ideal growth microenvironment With different components, fiber size and orientation, and seed cell types, electrospun scaffold complexes with different biochemical and mechanical properties can be tailored. The design and construction of vascular tissue engineering biomimetic ECMs are summarized, Role in vascular tissue engineering.