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目的评估急性脑梗塞尿激酶静脉溶栓治疗的疗效,并探讨作用机制。方法52例患者随机分为溶栓组和对照组,观察急性期溶栓治疗的疗效及并发症。结果溶栓组和对照组患者好转率分别为84.6%和46.1%,基本痊愈率溶栓组和对照组分别为73.1%和13.1%,经统计学处理,两组均有显著性差异(P<0.01)。其神经功能缺损平均减少分数,两组有极显著性差异(P<0.001)。结论溶栓治疗急性脑梗塞疗效确切,但存在一定的并发症。
Objective To evaluate the curative effect of intravenous thrombolytic therapy of urokinase in acute cerebral infarction and to explore the mechanism of action. Methods Fifty-two patients were randomly divided into thrombolysis group and control group. Efficacy and complications of acute thrombolytic therapy were observed. Results The improvement rates of the patients in the thrombolytic group and the control group were 84.6% and 46.1%, respectively. The basic cure rate was 73.1% and 13.1% in the thrombolytic group and the control group respectively. There was a significant difference between the two groups (P < 0.01). The neurological deficit reduced the average score, the two groups were significantly different (P <0.001). Conclusion Thrombolytic therapy of acute cerebral infarction is effective, but there are some complications.