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历史回顾和现状早在1816年Treille尸解因脓毒症死亡的士兵,发现胃粘膜有多发性糜烂。1842年Curling报道烧伤并发急性十二指肠溃疡的病例,遂称之为Curling溃疡。1932年Cushing报道颅内创伤和脑肿瘤病人伴有急性胃溃疡,其后誉之为Cushing溃疡。 50年代开始对烧伤并发应激性溃疡的问题引起广泛关注。第二次世界大战的经验阐明,积极输液可使严重烧伤病人渡过低血容量关,但是抗生素的临床应用仍不能避免烧伤后第二、三周发生的脓毒症。在此期间,常可发生消化道出血或穿孔。1950～1970年期间认为脓毒症并发消化道粘膜糜烂出血大多数位于十二指
Historical review and status quo As early as 1816 Treille dead body sepsis death soldiers, found that gastric mucosa have multiple erosion. Curling reported in 1842 cases of acute burns and acute duodenal ulcer cases, then called the Curling ulcer. 1932 Cushing report of intracranial trauma and brain tumor patients with acute gastric ulcer, followed by the reputation of Cushing ulcer. In the 1950s, there was widespread concern about the problem of stress ulcer associated with burn. The experience of World War II shows that active infusion can lead to severe burns patients through hypovolemia, but the clinical application of antibiotics still can not avoid the sepsis in the second and third weeks after burn. During this period, gastrointestinal bleeding or perforation can often occur. From 1950 to 1970 that sepsis with gastrointestinal mucosal erosion bleeding most located in the twelve