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白细胞介素8(IL-8)是一种具有趋化作用的小分子分泌型炎症性细胞因子,属于CXC趋化因子家族的成员,又名CXC趋化因子8(CXCL8)。近年研究发现体内多种细胞如单核细胞、巨噬细胞、内皮细胞、角质形成细胞、肿瘤细胞等都具有分泌IL-8的能力。IL-8与其相应受体CXCR1/2结合后,除了对中性粒细胞有趋化和诱导其脱颗粒作用外,还可以通过促进血管形成、影响肿瘤细胞增殖、存活及运动,在肿瘤的发生、发展和转移中发挥重要作用。本文主要综述了IL-8及其受体与膀胱癌生物学行为的关系。
Interleukin-8 (IL-8) is a chemotactic, small molecule, secreting, inflammatory cytokine that belongs to the CXC chemokine family, also known as CXC chemokine 8 (CXCL8). Recent studies have found that a variety of cells in the body such as monocytes, macrophages, endothelial cells, keratinocytes, tumor cells have the ability to secrete IL-8. IL-8 and its corresponding receptor CXCR1 / 2 binding, in addition to the chemotaxis and induction of neutrophil degranulation, but also by promoting the formation of blood vessels, affecting tumor cell proliferation, survival and movement in the occurrence of tumors , Development and transfer play an important role. This article reviews the relationship between IL-8 and its receptor and the biological behavior of bladder cancer.