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目的:观察清肝益气降压方单次和疗程给药对自发性高血压大鼠(SHR)血压的影响,探讨治未病理论指导下病证方药相结合组方模式的可行性。方法:根据原发性高血压初期的辨证分型和治法,将24只雄性自发性高血压大鼠随机分为模型对照组、清肝益气组、清肝泻火组和疏肝抑火组,测量单次给药后2 h、4 h、8 h的收缩压以及疗程给药42 d后的收缩压,观察血压变化情况,并以Wistar大鼠作空白对照。结果:清肝益气降压方有确切的降压作用,单次给药时清肝益气组大鼠给药后2 h、4 h的血压较给药前明显降低(P<0.05);疗程给药后清肝益气组与模型对照组相比血压明显下降(P<0.05)。结论:清肝益气降压方具有降压作用,说明病证方药结合的组方设计是一种极具临床价值的组方模式。
Objective: To observe the effect of qi-qi-qi-qi-qi prescription on the blood pressure of spontaneously hypertensive rats (SHR), and to explore the feasibility of combination of prescriptions and prescriptions under the guidance of disease-free theory. Methods: Twenty-four male spontaneously hypertensive rats were randomly divided into model control group, Qinggan Yiqi group, Qingganxianhuo group and Shugan Ganhuo group according to syndrome differentiation and treatment of primary hypertension. The systolic blood pressure at 2 h, 4 h and 8 h after single-dose administration and the systolic blood pressure at 42 d after administration were measured. The changes of blood pressure were observed and the Wistar rats were used as blank control. Results: The prescription of Qinggan Yiqi Jiangyin has a definite antihypertensive effect. The blood pressure of Qinggan Yiqi group at 2 h and 4 h after administration was significantly lower than that before administration (P <0.05). After treatment, the blood pressure of Qinggan Yiqi group was significantly lower than that of the model control group (P <0.05). Conclusion: Liver-qi and blood-pressure-lowering prescription has antihypertensive effects, indicating that the combination of prescriptions and prescriptions is a clinically valuable combination modality.