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目的 观察青少年盐敏感性的可重复性 ,对比观察盐敏感与盐不敏感性青少年血压的增龄性改变。方法 55名进行过急性盐水负荷和呋塞米缩容试验确定盐敏感性的青少年 ,于 5年后再次行静脉盐水负荷、呋塞米缩容试验 ,确定其盐敏感性的可重复性 ;比较 5年前、后均判定为盐敏感者的血压变化。结果 (1 )静脉盐水负荷、缩容试验判定盐敏感性 5年后测定的可重复性为 92 7%。(2 )盐敏感组青少年 5年血压的增长值和增长幅度均高于盐不敏感组 ,分别为 9 9 4 7mmHg (1mmHg=0 1 33kPa)和 9 7 6 4个百分点 ,特别以收缩压最为显著 (P <0 0 1 )。结论 静脉盐水负荷试验确定盐敏感性具有良好的远期可重复性 ;青少年盐敏感者血压随年龄的增长幅度远高于盐不敏感者 ,特别是收缩压
Objective To observe the reproducibility of salt sensitivity in adolescents and compare the age-related changes of blood pressure in salt-sensitive and salt-insensitive adolescents. Methods Fifty-five adolescents with salt sensitivity under acute saline load and furosemide shrinkage test were recruited. Five years later, the venous saline load and furosemide shrinkage test were again performed to determine the reproducibility of salt sensitivity. Five years ago, all were judged as salt sensitive blood pressure changes. Results (1) The variability of the salt sensitivity and the salt tolerance test after 5 years was 92.7%. (2) The 5-year blood pressure of salt sensitive group was higher than that of salt-sensitive group (9 9 4 7mmHg (1mmHg = 0 1 33kPa) and 9 7 6 4% respectively, especially in systolic blood pressure Significant (P <0.01). Conclusions The salt saline load test has good long-term reproducibility of salt sensitivity. The increasing rate of blood pressure of young salt-sensitive people with age is much higher than that of salt-sensitive ones, especially the systolic blood pressure