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蓖麻毒素(RT)是潜在军用毒剂和抗癌剂。RT是存在于蓖麻种子中的一种强细胞毒性糖蛋白,由A和B两条多肽链组成。B链上有半乳糖结合位点(GBS),可与细胞表面末端为半乳糖(Gal)的寡糖配体结合,然后使A链转入细胞液中,将核糖体60S亚单位催化失活,抑制蛋白质合成而使细胞死亡。由
Ricin (RT) is a potential military agent and anti-cancer agent. RT is a strong cytotoxic glycoprotein present in castor seeds, composed of two polypeptide chains, A and B. The B chain has a galactose binding site (GBS) that binds to the galactose (Gal) oligosaccharide ligand at the cell surface and then transfers the A chain into the cytosol, catalyzing the inactivation of the ribosomal 60S subunit , Inhibit protein synthesis and cell death. by