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在大鼠离体Ｌａｎｇｅｎｄｏｒｆ灌流心脏观察四丙酰关附醇胺（ＴＰＧＦＡ）对再灌性心律失常及心肌Ｎａ＋，Ｋ＋，Ｃａ２＋水平的影响．ＴＰＧＦＡ６－１２ｍｇＬ－１显著降低３０ｍｉｎ缺血＋３０ｍｉｎ复灌和吡那地尔（１．２５μｍｏｌＬ－１）＋１２ｍｉｎ缺氧＋４０ｍｉｎ再给氧两种模型的室性心动过速和心室纤颤发生率；ＴＰＧＦＡ３－１２ｍｇＬ－１可显著减慢心率，延长心电图的ＱＴｃ，减少Ｋ＋从心肌细胞内丢失；１２ｍｇＬ－１时还减少细胞内Ｃａ２＋堆积．结果表明ＴＰＧＦＡ可保护大鼠离体心脏的再灌性心律失常，其作用机理可能与抑制外向Ｋ＋电流有关．
The effects of TPGFA on the reperfusion arrhythmia and myocardial Na +, K + and Ca2 + levels were observed in the perfused heart of Langendorf rats. TPGFA6-12mgL-1 significantly reduced the incidence of ventricular tachycardia and ventricular fibrillation in 30 min ischemia / 30 min reperfusion and 1.25 mg / mL pinacidil + 12 min hypoxia + 40 min reoxygenation; TPGFA3- 12mgL-1 can significantly slow down the heart rate, prolong the QTc of electrocardiogram and reduce the loss of K + from cardiomyocytes; while decrease the intracellular Ca2 + accumulation when 12mgL-1. The results show that TPGFA can protect the isolated rat heart from reperfusion arrhythmia, its mechanism may be related to the inhibition of outward K + current.