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目的建立淄博地区健康孕妇妊娠各期甲状腺激素及促甲状腺激素(TSH)水平的正常参考值范围,了解淄博地区孕妇甲状腺疾病的发病情况,为临床诊断和治疗妊娠期甲状腺疾病提供依据。方法采用化学发光法检测2016年1-4月在淄博市妇幼保健院建档的单胎健康孕妇及年龄匹配的非妊娠女性的游离三碘甲状腺原氨酸(FT_3)、游离甲状腺素(FT_4)及TSH水平,经统计分析得到各孕期甲状腺激素水平的参考区间。结果不同孕期女性与孕前期女性FT_3、FT_4和TSH水平比较差异均有统计学意义(P<0.05)。孕早期、孕中期、孕晚期女性TSH水平均低于孕前期女性,随孕周增加而升高,孕早期最低。不同孕期女性FT_3和FT_4水平均低于孕前期女性,随孕周增加而降低。结论淄博地区孕妇妊娠期甲状腺激素水平与非妊娠女性有明显差异,建立淄博地区不同孕期女性甲状腺激素及TSH水平正常参考值范围对筛查和干预甲状腺疾病及优生优育至关重要。
Objective To establish a normal reference value range of thyroid hormone and thyroid stimulating hormone (TSH) levels in healthy pregnant women in Zibo area and to understand the incidence of thyroid disease in pregnant women in Zibo area and to provide basis for clinical diagnosis and treatment of thyroid disease during pregnancy. Methods The chemiluminescence method was used to detect free triiodothyronine (FT_3), free thyroxine (FT_4) and free thyroid hormone (FT_4) in healthy single-fetus and age-matched nonpregnant women. And TSH levels, the statistical analysis of thyroid hormone levels of pregnancy reference interval. Results There were significant differences in the levels of FT_3, FT_4 and TSH among different pregnant women and pre-pregnant women (P <0.05). The levels of TSH in the third trimester, third trimester and third trimester women were lower than those in pre-trimester women, increased with gestational age, and were lowest in early trimester. The levels of FT_3 and FT_4 in different pregnant women were lower than those in pre-pregnancy women and decreased with the increase of gestational age. Conclusion Pregnant women in Zibo area have significantly different thyroid hormone levels during pregnancy compared with non-pregnant women. Establishing a normal reference range of thyroid hormones and TSH levels in different pregnant women in Zibo area is very important for screening and intervention of thyroid disease and prenatal and postnatal care.