慢性乙型肝炎患者外周血单个核细胞mIL-2R表达

• 作 者: 王健 黄桂珍 张宁
• 机 构: 淮南工业学院医学分院病原学与免疫学教研室,淮南矿务局第三矿工医院
• 出 处: 蚌埠医学院学报
• 发表日期: 1999年02期
• 关键词: 乙型肝炎 mIL-2R 慢性乙肝 免疫测定 链霉亲和素 乙型病毒性肝炎 抗病毒免疫反应 白细胞介素 中膜 平行测定

目的：探讨慢性乙型肝炎（乙肝）患者外周血单个核细胞（ＰＢＭＣ）中膜白介素２受体（ｍＩＬ２Ｒ）在静息状态和诱导状态的表达水平及其与ＨＢｅＡｇ的关系。方法：用生物素链霉亲和素系统检测１０８例慢性乙肝患者ＰＢＭＣ的ｍＩＬ２Ｒ，并平行测定患者血清中ＨＢｅＡｇ。结果：在静息和诱导状态下，慢性乙肝患者的ｍＩＬ２Ｒ水平均低于正常对照组（Ｐ＜０．０５）；ＨＢｅＡｇ（＋）患者的ｍＩＬ２Ｒ水平也低于正常对照组（Ｐ＜０．０５和Ｐ＜０．０１）。结论：慢性乙肝患者ｍＩＬ２Ｒ表达水平低下，且与ＨＢｅＡｇ存在有关

Objective: To investigate the expression of mIL2R at resting and induced status in peripheral blood mononuclear cells (PBMC) from patients with chronic hepatitis B (HB) and its relationship with HBeAg. Methods: Biotin-streptavidin system was used to detect the mIL2R in PBMC from 108 patients with chronic hepatitis B, and the serum HBeAg was measured in parallel. Results: The levels of mIL-2R in patients with chronic hepatitis B were lower than those in normal controls (P <0.05) at resting and induced status. The levels of mRR in patients with HBeAg (+) were also lower than those in controls <0.05 and P <0.01). Conclusion: The expression of mIL2R in patients with chronic hepatitis B is low and related to the existence of HBeAg