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目的观察奥曲肽联合泮托拉唑治疗急性上消化道出血的临床疗效。方法选取2015年12月—2016年12月收治的200例急性上消化道出血患者,随机分为对照组和观察组,各100例。所有患者给予禁食、置胃管、补充血容量等常规治疗,在此基础上对照组给予泮托拉唑治疗,观察组给予泮托拉唑+奥曲肽治疗,比较两组持续出血时间、总输血量、胃液p H值、血红蛋白水平以及治疗有效率。计量资料比较采用t检验;计数资料比较采用χ2检验,P<0.05为差异具有统计学意义。结果观察组持续出血时间[(15.14±4.59)h]比对照组[(25.45±6.28)h]短,总输血量[(150.22±26.94)m L]比对照组[(205.85±25.96)m L]少,胃液的p H值(5.89±0.62)比对照组(4.53±0.55)大,血红蛋白水平[(120.79±9.56)g/L]比对照组[(101.81±9.20)g/L]高,差异有统计学意义(均P<0.05)。观察组有效率(92.00%)高于对照组(70.00%),差异有统计学意义(P<0.05)。结论奥曲肽联合泮托拉唑治疗急性上消化道出血与单一使用泮托拉相比,止血时间更快,输血量更少。
Objective To observe the clinical efficacy of octreotide combined with pantoprazole in the treatment of acute upper gastrointestinal bleeding. Methods A total of 200 acute upper gastrointestinal bleeding patients who were admitted from December 2015 to December 2016 were randomly divided into control group and observation group, with 100 cases each. All patients were given regular treatment of fasting, gastric tube, blood volume replacement, on the basis of the control group given pantoprazole treatment, the observation group was given pantoprazole + octreotide treatment, the two groups were compared the duration of bleeding, the total blood transfusion Volume, p H value of gastric juice, hemoglobin level, and therapeutic effectiveness. Measurement data were compared using t test; count data were compared using χ2 test, P <0.05 for the difference was statistically significant. Results The duration of continuous bleeding in the observation group [(15.14 ± 4.59) h] was shorter than that in the control group [(25.45 ± 6.28) h] and the total blood transfusion was (150.22 ± 26.94) m L (P <0.01). The p value of gastric juice (5.89 ± 0.62) was higher than that of the control group (4.53 ± 0.55), and hemoglobin level was (120.79 ± 9.56) g / L higher than that of the control group (101.81 ± 9.20 g / L) The difference was statistically significant (all P <0.05). The observation group (92.00%) was higher than the control group (70.00%), the difference was statistically significant (P <0.05). Conclusions The combination of octreotide and pantoprazole in the treatment of acute upper gastrointestinal bleeding has faster hemostasis and less blood transfusion than single pantoprazole.