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急性胃十二指肠损伤通常与使用非甾体抗炎药有关,其损伤机制尚不十分清楚.本文研究的目的是为了评估具有不同程度抑酸作用的两种药物对萘普生所致胃十二指肠损伤的保护作用.年龄 22～28岁的15例志愿者,治疗前后按Lanza记分法,从0到4分成不同等级.将志愿者双盲随机分为安慰剂组和给药组(雷尼替丁150mg,2次/d;奥美拉唑40mg)给药7天,并在第3～7天给予萘普生500mg,2次/d.结果,安慰剂组胃损伤的平均记分为1.53,雷尼替丁和奥美拉唑组与安慰剂组比较,胃损伤记分分别减少44%和40%,但两药间差异无显著性.约70%胃粘膜损伤于胃窦部.安
Acute gastroduodenal injury is usually associated with the use of non-steroidal anti-inflammatory drugs, the damage mechanism is not yet clear.The purpose of this study is to assess the effect of two drugs with varying degrees of inhibition of acid-induced naproxen stomach Protective effects of duodenal injury 15 volunteers aged 22 to 28 years old, before and after treatment according to Lanza score, divided into different grades from 0 to 4. The volunteers were randomly divided into placebo and placebo group (Ranitidine 150 mg, twice daily, omeprazole 40 mg) for 7 days and naproxen 500 mg twice daily on days 3 to 7. As a result, the average gastric lesions in the placebo group Scoring 1.53, compared with placebo group, ranitidine and omeprazole group decreased 44% and 40%, respectively, but no significant difference between the two drugs.About 70% gastric mucosal injury in the gastric antrum Ann