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目的:研究亚临床甲减对初诊2型糖尿病(T2DM)患者血压的影响。方法:选取2012年我院内分泌科住院初诊为T2DM患者,检测血糖、血脂、糖化血红蛋白(HbA1c)、甲状腺功能,并选择其中甲状腺功能正常者(对照组)和亚临床甲状腺功能减退者(亚临床甲减组)为研究对象。分别测量两组的血压、身高、体重,比较两组的收缩压(SBP)、舒张压(DBP),了解亚临床甲减与T2DM患者血压的相互关联。结果:(1)血清促甲状腺激素(TSH)与SBP和DBP均存在正相关关系,在校正了年龄、性别、吸烟、体重指数(BMI)、血糖、血脂的影响后,血清TSH与SBP和DBP的正向相关性依然存在;按性别分层发现,这种正相关关系在女性中尤其明显(相关系数r分别为0.116、0.130,P分别为0.007、0.002);(2)亚临床甲减组的SBP和DBP水平高于甲状腺功能正常对照组。结论:随着血清TSH的增加,SBP和DBP有所升高,亚临床甲减会增加T2DM患者高血压患病风险。
Objective: To study the effect of subclinical hypothyroidism on blood pressure in newly diagnosed type 2 diabetic patients (T2DM). Methods: The first visit of T2DM patients admitted to Department of Endocrinology in our hospital in 2012 was performed to detect the levels of blood glucose, blood lipid, HbA1c and thyroid function, and the patients with normal thyroid function (control group) and subclinical hypothyroidism Hypothyroidism group) as the research object. The blood pressure, height and weight of the two groups were measured respectively. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the two groups were compared to understand the correlation between subclinical hypothyroidism and blood pressure in T2DM. Serum thyrotropin (TSH) was positively correlated with both SBP and DBP. After adjusting for age, gender, smoking, body mass index (BMI), blood glucose, (R = 0.116,0.130, P = 0.007,0.002, respectively); (2) In the subclinical hypothyroidism group, the positive correlation still exists; The SBP and DBP levels were higher than those in the normal thyroid function control group. Conclusion: With the increase of serum TSH, SBP and DBP have increased, subclinical hypothyroidism will increase the risk of hypertension in T2DM patients.