论文部分内容阅读
椎体是非小细胞肺癌(NSCLC)骨转移的常见部位,脊神经和马尾受压后会导致脊髓压迫综合征(SCCS)。SCCS是一种肿瘤急症,需要立即治疗减轻疼痛和保护神经功能。肺癌合并SCCS的患者生存期较短。本文报道1例非小细胞肺癌合并脊髓压迫导致截瘫的患者,椎体减压固定后不能耐受放化疗,口服吉非替尼(250 m.gd-1)治疗,无疾病进展期是27月,生存期达到28月。所以,对于合并SCCS的NSCLC患者,联合表皮生长因子受体-酪氨酸激酶抑制剂(EGFR-TKI)的综合治疗是一个较好的选择。
The vertebral body is a common site of bone metastases in non-small cell lung cancer (NSCLC). Compression of the spinal nerves and cauda leads to spinal cord compression syndrome (SCCS). SCCS is a tumor emergency that requires immediate treatment to relieve pain and protect neurological function. Patients with lung cancer with SCCS have a shorter survival period. This paper reports a case of non-small cell lung cancer with paraplegia caused by spinal cord compression in patients with vertebroplasty decompression can not tolerate radiotherapy and chemotherapy after oral gefitinib (250 m.gd-1) treatment, disease progression is 27 months , The survival period reached 28 months. Therefore, the combination of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) is a good choice for NSCLC patients with SCCS.