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为评价孕妇自身免疫性甲状腺病在先天甲状腺功能低下新生儿的发病率中的重要性进行研究。 1984～1996年间Quebec新生儿筛查发现甲状腺功能低下259例(甲低),常规在产后1～3周检查母婴血液中游离甲状腺素(T_4)、TSH及抗微粒体抗体,有异常TSH或抗微粒体抗体阳性婴儿的母亲在1997年春天重复第3次测定TSH。1991～1992年间正常孕妇1773例为对照组,常规孕中期产前筛查AFP及hCG,同时测定游离T_4、TSH及抗微粒体抗体。其中7例因患Graves病而用propylthiouracil,
To evaluate the importance of autoimmune thyroid disease in pregnant women with congenital hypothyroidism and neonatal morbidity. From 1984 to 1996, 259 cases of hypothyroidism (hypothyroidism) were found in neonatal screening in Quebec, and free thyroid hormone (T_4), TSH and anti-microsomal antibodies were detected in maternal and neonatal blood 1 to 3 weeks postpartum. Abnormal TSH or The mother of an anti-microsomal antibody-positive infant repeated the third determination of TSH in the spring of 1997. A total of 1773 pregnant women from 1991 to 1992 were selected as the control group. AFP and hCG were routinely detected in the second trimester of pregnancy. Free T_4, TSH and anti-microsomal antibodies were also detected. 7 cases of Graves disease due to suffering with propylthiouracil,