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目的 探讨血清胰岛素佯生长因子(IGFs)与胎儿出生体重、身长、胎盘重量和血糖浓度的关系。方法 21只孕鼠分为宫内生长迟缓组(IUGR)和对照组。检测2组胎鼠血清IGF-Ⅰ、IGF-Ⅱ水平,血糖浓度及胎鼠出生体重、身长,并进行比较和相关分析。结果 IUGR胎鼠的血清IGF-Ⅰ、IGF-Ⅱ、血糖浓度、胎盘重量及出生体重、身长均较对照组明显降低(P<0.01);IGF-Ⅰ、IGF-Ⅱ水平与出生体重、身长、胎盘重量、血糖浓度均呈正相关。结论IGF-Ⅰ、IGF-Ⅱ均可能为胎儿宫内发育重要的促生长因子,对胎儿血糖水平的稳定具有重要的调节作用。
Objective To investigate the relationship between serum insulin-like growth factor (IGFs) and fetal birth weight, body length, placental weight and blood glucose concentration. Methods Twenty-one pregnant rats were divided into intrauterine growth retardation group (IUGR) and control group. The serum IGF-Ⅰ, IGF-Ⅱ levels, blood glucose levels and fetus birth weight and body length were measured in two groups of fetuses and compared and analyzed. Results The serum levels of IGF-Ⅰ, IGF-Ⅱ, blood glucose, placental weight, birth weight and length in IUGR fetus were significantly lower than those in control group (P <0.01) Placental weight, blood glucose concentrations were positively correlated. Conclusion Both IGF-Ⅰ and IGF-Ⅱ may play an important role in the development of intrauterine fetal growth-promoting factor, which plays an important role in the regulation of fetal blood glucose level.