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胃肠道有多种生物学活性肽,在胃肠道起激素或神经递质作用。胃肠道粘膜也有一种特殊的细胞,称为“旁分泌”细胞,其外形似内分泌细胞,但有树状突出与其他细胞广泛接触,并在局部释放分泌物质控制其他细胞的活动。可以设想这种复合结构能控制胃酸分泌、胃排空和粘膜血流等多种功能。目前的技术虽然未能阐明单个多肽的生理功能,但对Zollinger-Ellison综合征(ZES)的发病机理已认识清楚。
The gastrointestinal tract has a variety of biologically active peptides that act as hormones or neurotransmitters in the gastrointestinal tract. Gastrointestinal mucosa also has a special type of cells, called “paracrine” cells, which resemble endocrine cells but have dendritic prominence in extensive contact with other cells and locally release secreted substances to control the activity of other cells. It is conceivable that this composite structure can control various functions such as gastric acid secretion, gastric emptying and mucosal blood flow. Although the current technology failed to elucidate the physiological function of a single polypeptide, the pathogenesis of Zollinger-Ellison syndrome (ZES) is well understood.