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为观察自身免疫性甲状腺炎（ＨＤ） 腺体内淋巴细胞Ｆａｓ－ Ｌ的表达及血清ｓＡＰＯ－ １／Ｆａｓ的测定， 与ＨＤ病因及临床意义的关联。本文应用抗链霉菌抗生素蛋白－ 过氧化酶连接法（ＳＰ法）对甲状腺细胞学涂片进行淋巴细胞Ｆａｓ－ Ｌ 的表达的观察； 并应用ＥＬＩＳＡ 法测定血清ｓＡＰＯ－ １／Ｆａｓ。结果表明， ＨＤ 腺体内淋巴细胞Ｆａｓ－ Ｌ的表达显著高于ＧＤ 组和对照组， Ｐ＜ ０ ．００１ ；血清ｓＡＰＯ－ １／Ｆａｓ 水平，ＨＤ低于ＧＤ、对照组和正常组，Ｐ＞ ０ ．０５ 。上述结果提示，ＨＤ腺体内淋巴细胞Ｆａｓ－ Ｌ表达的观察， 有助于评估ＨＤ治疗方法， 对治疗结果的影响，并对ＨＤ的发展和预后进行判断。
To investigate the expression of Fas-L in lymphocytes and the determination of serum sAPO-1 / Fas in autoimmune thyroiditis (HD) gland, and its association with etiology and clinical significance of HD. In this paper, anti-streptomycin antibiotic protein-peroxidase connection method (SP method) of thyroid cytology smear lymphocyte Fas-L expression was observed and measured by ELISA sAPO-1 / Fas. The results showed that the expression of Fas-L in lymphocytes in HD gland was significantly higher than that in GD and control groups, P <0. 001; serum sAPO-1 / Fas levels, HD lower than GD, control group and normal group, P> 05. The above results suggest that the observation of the expression of Fas-L in lymphocytes in HD gland may help to evaluate the effect of HD treatment on the outcome of treatment and to judge the development and prognosis of HD.