从红树林内源真菌2526#分离到的Sterig matocystin

• 作 者: 朱峰 林永成 周世宁 L.L.P.Vrijmoed
• 机 构: 中山大学化学与化学工程学院,中山大学化学与化学工程学院,中山大学生命科学学院,香港城市大学生物学和化学系 广州510275,佛山科学技术学院化学与化工系佛山,广州510275,广州,香港
• 出 处: 应用化学
• 发表日期: 2003年03期
• 关键词: 细胞毒 内源 生源合成 反复硅胶柱层析 石油醚 元素分析 甲醇提取 海洋微生物 粗海盐 分子离子峰

Compound A was isolated from endophytic fungus( No.2526) of mangrove Avicennia from the South China Sea. The structure of compound A was elucidated by compr ehensive spectral data and coincided with that of sterigmatocystin. Compound A s howed a weak cytotoxic activity against Bel-7402 and NCIH-460 in vitro wit h IC 50 96 53×10 -6 and 72 52×10 -6 g/mL respectively. It is the first report on sterigmatocystin that isolated from marine fungus.

Compound A was isolated from endophytic fungus ( No.2526) of mangrove Avicennia from the South China Sea. The structure of compound A was elucidated by compr ehensive spectral data and coincided with that of sterigmatocystin. Compound A s howed a weak cytotoxic activity against Bel -7402 and NCIH-460 in vitro wit h IC 50 96 53×10 -6 and 72 52×10 -6 g/mL respectively. It is the first report on sterigmatocystin that isolated from marine fungus.