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目的:探讨YKL-40在川崎病(KD)发病中的作用,及其与KD冠状动脉病变(CAL)之间的关系。方法:收集2015-06-2016-06在武汉市妇女儿童医疗保健中心住院的KD患儿86例,将其分为KD无CAL组72例、KD伴CAL组14例,并随机选取同期住院的上呼吸道感染并发热患儿40例作为对照组,比较各组血清YKL-40、白细胞(WBC)、血小板(PLT)、C反应蛋白(CRP)、红细胞沉降率(ESR)、纤维蛋白原(FIB)水平的差异。结果:KD无CAL组YKL-40、WBC、PLT、CRP、ESR、FIB水平均较对照组明显升高,差异有统计学意义(P<0.01)。KD伴CAL组血清YKL-40水平较KD无CAL组明显升高,差异有统计学意义(P<0.01),而两组WBC、PLT、CRP、ESR、FIB水平无显著性差异(P>0.05)。结论:YKL-40可能参与了KD的发病,可作为KD冠状动脉损伤的一种新的预测指标。
Objective: To investigate the role of YKL-40 in the pathogenesis of Kawasaki disease (KD) and its relationship with KD coronary artery disease (CAL). METHODS: A total of 86 KD children hospitalized in Wuhan Women’s and Children’s Medical Center were collected from June 2015 to June 2016. They were divided into KD without CAL in 72 cases, KD with CAL in 14 cases, and randomized inpatients 40 children with upper respiratory tract infection and fever were selected as control group. Serum levels of YKL-40, WBC, PLT, CRP, ESR, fibrinogen (FIB) ) The level of difference. Results: The levels of YKL-40, WBC, PLT, CRP, ESR and FIB in KD without CAL group were significantly higher than those in control group (P <0.01). The level of serum YKL-40 in KD with CAL group was significantly higher than that in KD without CAL group (P <0.01), but there was no significant difference in WBC, PLT, CRP, ESR and FIB between the two groups ). Conclusion: YKL-40 may be involved in the pathogenesis of KD, which can be used as a new predictor of KD coronary artery injury.