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导言流行病学调查已表明人群的平均食盐摄入量与高血压的发生呈正相关。高血压病人减少食盐摄入,其血压就下降。动物试验揭示了降压的可能机制。此外,临床和流行病学研究认为钾有保护作用。Lucia S的“人群研究”,尽管尿钠平均排出量高,平均血压却比报导的美国Evans县白人、黑人以及印度西部的其他人群的平均血压低。然而尿钾也高,钠、钾的比率比Evans县人群者低。这个人群内的个体血压也和个体的钾/肌酸酐比率呈负相关,与采集的尿样的钠、钾比率呈正相关。因此,进行这次试验以观察食用通常的西方膳食(即高钠)食谱,增加钾后是否能降低正常人的平均血压。
Introduction Epidemiological investigations have shown that there is a positive correlation between the average salt intake in the population and the incidence of hypertension. Hypertensive patients to reduce salt intake, its blood pressure drops. Animal experiments revealed a possible mechanism of blood pressure reduction. In addition, clinical and epidemiological studies suggest that potassium has a protective effect. Lucia S’s Census of Population, mean high blood pressure despite average urinary sodium excretion, is lower than the average blood pressure reported for White, Black, and other people in western Evans, USA. However, urinary potassium is also high, with a lower sodium and potassium ratio than Evans County. The individual’s blood pressure in this population is also negatively correlated with the individual’s potassium / creatinine ratio, which is positively correlated with the sodium and potassium ratios of the collected urine samples. Therefore, this trial was conducted to see if recipes for consuming the usual Western diet (ie, high sodium) were given, and whether increasing potassium increased the mean blood pressure of normal people.