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采用 EL ISA方法检测旋毛虫病患者血清中各类特异性抗体 ,结果表明 :特异性抗体检出率依次是 Ig G、Ig E、Ig D、Ig A和 Ig M,其中全部病人血清中均有特异性 Ig G,90 .0 %的病人检出特异性 Ig E,86 .6 7%的病人检出特异性 Ig D;Ig G是旋毛虫感染免疫中最具保护作用的抗体 ,检出率高且半衰期长 ,故首选特异性 Ig G作为免疫诊断的指标 ;特异性 Ig E在旋毛虫感染中能介导保护性免疫 ,并能介导速发型超敏反应引起免疫病理损伤 ,Ig E是旋毛虫等蠕虫感染免疫中值得注意的免疫球蛋白 ;本实验中观察到血清特异性 Ig D检出率较高 ,但 Ig D确切的免疫机理尚不清楚。提示应根据不同的目的 ,检测不同类型的特异性抗体。对血清各类抗体的检测 ,可反映机体感染旋毛虫后的免疫状态。
The results showed that the detection rate of specific antibodies were Ig G, Ig E, Ig D, Ig A and Ig M in serum of all the patients Specific Ig G, 90.0% of the patients detected specific Ig E, 86.67% of the patients detected specific Ig D; Ig G is Trichinella infection immunity most protective antibody, the detection rate High and long half-life, so the preferred specificity Ig G as an indicator of immune diagnosis; specific Ig E in Trichinella infection can mediate protective immunity and can induce immediate hypersensitivity caused by immunopathological damage IgE Trichinella and other worms infected with immunoglobulin of immunological noteworthy; observed in this experiment, serum specific Ig D detection rate, but Ig D exact immune mechanism is unclear. Tip should be based on different purposes, testing different types of specific antibodies. Detection of various types of antibodies to serum, can reflect the immune status of infected Trichinella.