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运用ＳｏｕｔｈｅｒｎＢｌｏｔ技术分析１０９例慢性乙型肝炎患者外周血Ｔ细胞受体基因β链（ＴｃｅｌｒｅｃｅｐｔｏｒｇｅｎｅＢｅｔａｃｈａｉｎ，ＴＣＲβ）重组。发现有４．５ｋｂ，５．０ｋｂ，２１ｋｂＥｃｏＲ１重组带和５．５ｋｂ，１６ｋｂ，１８ｋｂＨｉｎｄⅢ重组带。白人患者的５．０ｋｂＥｃｏＲ１和５．５ｋｂＨｉｎｄⅢ重组带出现的频率（分别为４４．４％）高于亚裔患者（１０．８％和１８．８％）和土著患者（１５．６％和２５．６％）。表明：慢性乙型肝炎患者对ＨＢＶ的应答由寡克隆参与，优势克隆分别由Ｃ１区和Ｃ２区参与重组，白人患者对ＨＢＶ感染有较强的应答能力。
Southern blot was used to analyze the T cell receptor gene beta chain (TCRβ) rearrangement in 109 cases of chronic hepatitis B patients. Found 4.5kb, 5.0kb, 21kbEcoR1 recombination and 5.5kb, 16kb, 18kbHindIII recombinant band. The frequencies of the 5.0kbEcoR1 and 5.5kbHindIII recombination bands in white patients (44.4%, respectively) were higher in Asian patients (10.8% and 18.8%) and in indigenous patients (15.6% and 25%). 6%). The results showed that the response of HBV to chronic hepatitis B was mediated by oligoclonal clones, and the dominant clones were involved in the recombination by C1 and C2 respectively. The white patients had a strong response to HBV infection.