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采用Y-迷宫分辨学习和1次被动回避反应2种行为模型,利用小鼠海马内微注射技术,检测了钙通道拍抗剂尼莫地平的中枢效应,并观测了开场行为。结果表明,海马内钙离子水平升高会破坏KM小鼠的分辨学习能力及1次被动回避反应的记忆保持。尼莫地平对正常小鼠的分辨学习无明显影响,但可促进小鼠1次被动回避反应的记忆保持,并可对抗海马内Ca~(2+)水平升高引起的小鼠分辨学习障碍及记忆保持的破坏。
Y-maze discrimination learning and one passive avoidance reaction were used to detect the central effect of calcium channeling antagonist nimodipine by microinjection of mouse hippocampus, and the opening behavior was observed. The results showed that elevated levels of calcium in the hippocampus would destroy the ability of KM mice to distinguish learning and memory retention of a passive avoidance response. Nimodipine has no significant effect on the discrimination learning of normal mice, but it can promote the memory retention of passive avoidance reaction in mice and can antagonize the learning disability of mice caused by elevated Ca 2+ in hippocampus and Memory to maintain the destruction.