Inhibitory Effects of Roscovitine on Proliferation and Migration of Vascular Smooth Muscle Cells In

• 作 者: 张双双 王伟 赵崇强 谢敏杰 李闻宇 杨向俐 吕家高
• 机 构: DepartmentofCardiovascularMedicine,DepartmentofCardiovascularMedicine,DepartmentofNeurology
• 出 处: 华中科技大学学报：医学英德文版
• 发表日期: 2014年6期
• 关键词: 血管平滑肌细胞 体外增殖 抑制作用 细胞周期蛋白依赖性激酶 迁移 浓度依赖性 细胞生长 流式细胞仪 roscovitine vascular smooth mu
• 基金项目: This project was supported by grants from the National Natu- ral Science Foundation of China （Nos. 30870641 and 81030021）, and the National Basic Research of China “973” Program （No. 2011CB504403）.

Abnormal proliferation and migration of vascular smooth muscle cells(VSMCs) are the major cause of in-stent restenosis(ISR). Intervention proliferation and migration of VSMCs is an important strategy for antirestenotic therapy. Roscovitine, a second-gener