Antisense RNA of Survivin Gene Inhibits the Proliferation of Leukemia Cells and Sensitizes Leukemia

• 作 者: 李文涵 王晓娟 雷萍 叶庆 朱慧芬 张悦 邵静芳 杨敬 沈关
• 机 构: DepartmentofImmunology,DepartmentofPathobiologyandPhysiology
• 出 处: 华中科技大学学报：医学英德文版
• 发表日期: 2008年1期
• 关键词: 白血病 细胞增生 化学治疗 细胞凋亡 survivin leukemia antisense RNA taxol apoptosis proliferation
• 基金项目: This project was supported by grants from the 863 program of China （No.2006AA02Z158） and Wuhan Development Program of China （No. 2003500201628）.

The effects of survivin antisense RNA on proliferation of leukemia cell line HL-60 and taxol-induced chemotherapy was explored. A cDNA fragment of survivin obtained by RT-PCR was inserted into a plamid vector named pcDNA3 in the reverse direction. The vec