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目的 研究血管内皮生长因子 (VEGF)、碱性成纤维细胞生长因子 (b FGF)、转化生长因子β1 (TGF-β1 )及其受体和肿瘤源性粘附因子 (TAF)在咽喉部恶性黑色素瘤中的表达特点 ,以及它们与肿瘤内微血管密度(MVD)和病人预后的关系。 方法 应用免疫组织化学和形态计量方法检测 2 8例咽喉部恶性黑色素瘤 MVD、VEGF、b FGF、TGF- β1 及其受体和 TAF的表达 ,并应用多因素 Cox比例风险模型检测上述因素和病人预后的关系。 结果 2 8例咽喉部恶性黑色素瘤中 ,VEGF阳性 19例 (6 7.9% ) ,b FGF阳性 2 1例 (75 .5 % ) ,TGF- β1 阳性 16例 (5 7.1% ) ,TAF阳性 18例 (6 4.3% )。血管生成因子与其受体表达具有一致性 ,并与 MVD值显著相关。Cox模型分析显示 MVD和 VEGF是影响咽喉部恶性黑色素瘤的重要因素 (P<0 .0 5 )。 结论 VEGF、b FGF、TGF- β1 和TAF是咽喉部恶性黑色素瘤中血管生成的重要因子 ,并通过促进血管生成影响病人的预后。其中 MVD和 VEGF是评估咽喉部恶性黑色素瘤病人预后的重要指标。
Objective To investigate the effect of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b FGF), transforming growth factor β1 (TGF-β1) and its receptor and tumor-derived adhesion factor Tumor characteristics and their relationship with tumor microvessel density (MVD) and the prognosis of patients. Methods The expression of MVD, VEGF, bFGF, TGF-β1 and its receptor and TAF in 28 cases of throat malignant melanoma were detected by immunohistochemistry and morphometry. The multifactorial Cox proportional hazards model was used to detect the above-mentioned factors and patients Prognosis of the relationship. Results Of the 28 patients with malignant throat, 19 (6 7.9%) were positive for VEGF, 21 (75.5%) were positive for b FGF, 16 (5 7.1%) were positive for TGF- (6 4.3%). Angiogenic factors were consistent with their receptor expression and significantly correlated with MVD. Cox model analysis showed that MVD and VEGF were the important factors influencing throat malignant melanoma (P <0.05). Conclusion VEGF, b FGF, TGF-β1 and TAF are important factors of angiogenesis in throat malignant melanoma and may affect the prognosis of patients by promoting angiogenesis. Which MVD and VEGF is to assess the prognosis of throat malignant melanoma patients an important indicator.