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目的 通过测定直肠癌患者外科切除术前后外周血白细胞介素２（ＩＬ－ ２） 活性及淋巴细胞刺激指数（ＬＳＩ） 的变化，了解患者机体免疫功能。方法 选取直肠癌患者２０ 例，分别在术前及术后７，１４，２１，２８ ｄ 抽取外周血测定ＩＬ－２ 活性及ＬＳＩ变化。结果 直肠癌患者外周血ＩＬ－ ２ 及ＬＳＩ均显著降低，术后７ ｄ 进一步降低，至术后１４ ｄ 逐渐恢复。结论 ①直肠癌患者机体免疫功能下降；②外科根治切除术可使机体在术后短期内免疫功能进一步降低，但随着时间延长可显示出促进恢复作用。
Objective To understand the immune function of patients by recognizing the changes of interleukin-2 (IL-2) activity and lymphocyte stimulation index (LSI) in patients with rectal cancer before and after surgical resection. Methods Twenty patients with rectal cancer were selected. Peripheral blood was collected before operation and 7, 14, 21, and 28 days after operation to determine IL-2 activity and LSI changes. Results The IL-2 and LSI in peripheral blood of patients with rectal cancer were significantly lower, and they were further decreased 7 days after surgery, and gradually recovered after 14 days. Conclusion 1 The immune function of patients with rectal cancer is decreased. 2 The radical resection of the surgery can reduce the immune function of the body in the short-term after operation, but it can be shown to promote recovery as the time goes by.