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目的:子宫颈癌(Cervical Cancer)是女性生殖系统常见的恶性肿瘤,严重影响女性的身体健康及生活质量。本研究通过观察单纯放疗与同步放化疗治疗中晚期宫颈癌的临床效果,探讨治疗宫颈癌的最佳方式,为后续临床研究提供参考。方法:选取我院2008年1月-2009年6月收治的中晚期宫颈癌患者124例,随机分为同步放化疗组和单纯放疗组,每组62例。单纯放疗组采取腔内或腔外照射的方式进行放射治疗,而同步放化疗组在此基础上采用多烯紫杉醇+顺铂(DP)方案进行治疗。观察并比较两组患者的近期临床疗效、毒副反应发生率及随访情况。结果:同步放化疗组的治疗总有效率、毒副反应发生率均高于单纯放疗组,但患者经对症处理后均获得改善;同步放化疗组三年生存率高于单纯放疗组,差异均具有统计学意义(P<0.05)。结论:在中晚期宫颈癌的临床治疗中,对患者实施放射治疗的同时选择合理的药物及给药方案进行化疗具有明显的近期疗效,患者的毒副反应可耐受,且治疗后的生存率较高,值得临床推广应用。
Objective: Cervical Cancer is a common malignant tumor of the female reproductive system, seriously affecting the health and quality of life of women. This study observed the clinical efficacy of radiotherapy and concurrent chemoradiotherapy in the treatment of advanced cervical cancer, to explore the best way to treat cervical cancer, provide reference for follow-up clinical research. Methods: A total of 124 patients with advanced cervical cancer who were admitted to our hospital from January 2008 to June 2009 were randomly divided into concurrent radiochemotherapy group and radiotherapy alone group, with 62 patients in each group. In the radiotherapy group, radiotherapy was performed by means of intracavitary or extracavitary irradiation, while concurrent radiotherapy and chemotherapy group was treated with docetaxel + cisplatin (DP) on this basis. The clinical efficacy, the incidence of adverse reactions and the follow-up were observed and compared between the two groups. Results: The total effective rate and the incidence of toxic and side effects of concurrent chemoradiotherapy group were higher than that of radiotherapy alone group, but the symptomatic treatment patients were improved. The three-year survival rate of concurrent chemoradiotherapy group was higher than that of radiotherapy alone group Statistically significant (P <0.05). Conclusion: In the clinical treatment of advanced cervical cancer, the patients who received radiotherapy at the same time choose a reasonable drug and dosing regimens for chemotherapy have significant short-term efficacy, the patient’s toxicity can be tolerated, and the survival rate after treatment Higher, it is worth to promote clinical application.