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目的探讨奥拉西坦联合长春西汀注射液治疗一氧化碳中毒迟发性脑病患者的临床效果。方法 64例一氧化碳中毒迟发性脑病患者,根据入院时间先后分为观察组和对照组,各32例。对照组在常规治疗基础上给予长春西汀注射液治疗,观察组则在对照组治疗基础上添加奥拉西坦注射液治疗,对比两组患者治疗效果。结果观察组患者治疗总有效率为93.8%;高于对照组的78.1%(P<0.05);治疗后观察组蒙特利尔认知评估量表(Mo CA)评分、简易精神状态评估量表(MMSE)评分均明显高于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论奥拉西坦联合长春西汀注射液治疗一氧化碳中毒迟发性脑病患者效果显著,值得临床推广。
Objective To investigate the clinical efficacy of oxiracetam combined with vinpocetine injection in the treatment of patients with delayed encephalopathy caused by carbon monoxide poisoning. Methods Sixty-four patients with delayed encephalopathy after carbon monoxide poisoning were divided into observation group and control group according to the time of admission, with 32 cases in each group. The control group was treated with Vinpocetine injection on the basis of routine treatment. The observation group was treated with oxiracetam injection on the basis of the control group, and the treatment effect was compared between the two groups. Results The total effective rate was 93.8% in the observation group and 78.1% in the control group (P <0.05). After the treatment, the Montreal Cognitive Assessment Scale (MoCA), the Mini-Mental Status Assessment Scale (MMSE) (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusions Oxiracetam combined with vinpocetine injection in the treatment of patients with delayed encephalopathy caused by carbon monoxide poisoning is effective and worthy of clinical promotion.