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目的研究IL-6、MMP-9、TNF-α在未足月胎膜早破早产孕妇的血清、羊水中的含量及表达,探讨其与胎膜早破早产的关系。方法采用酶联免疫吸附法检测30例胎膜早破早产孕妇(PPROM组)与20例正常孕妇(对照组)血清和羊水中的IL-6、MMP-9、TNF-α的含量,同时进行胎膜的病理检查。结果 PPROM组母血清及羊水中IL-6、MMP-9的含量均高于对照(P<0.05),羊水中TNF-α的含量较对照组高(P<0.05)。PPROM组绒毛膜羊膜炎者血清、羊水中IL-6、TNF-α(P<0.05)、MMP-9(P<0.01)水平均高于非绒毛膜羊膜炎者。结论孕妇血清、羊水中IL-6、MMP-9、TNF-α水平与PPROM感染引起的早产有关,检测其水平可作为PPROM良好的预测指标。
Objective To study the content and expression of IL-6, MMP-9 and TNF-α in serum and amniotic fluid of premature rupture of pregnant women without full term preterm premature rupture of membranes and to explore its relationship with premature rupture of membranes. Methods Serum and amniotic fluid levels of IL-6, MMP-9 and TNF-α in 30 preterm premature rupture membranes pregnant women (PPROM group) and 20 normal pregnant women (control group) were measured by enzyme-linked immunosorbent assay Membrane pathology examination. Results The levels of IL-6 and MMP-9 in serum and amniotic fluid in PPROM group were higher than those in control group (P <0.05). The content of TNF-α in amniotic fluid was higher than that in control group (P <0.05). The levels of IL-6, TNF-α (P <0.05), MMP-9 (P <0.01) in PPROM chorioamnionitis serum and amniotic fluid were higher than those in non-chorioamnionitis. Conclusion The levels of IL-6, MMP-9 and TNF-α in serum and amniotic fluid of pregnant women are related to the premature delivery caused by PPROM infection. The detection of IL-6, MMP-9 and TNF-α levels can be used as a good predictor of PPROM.