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目的：探讨表达ＣＤ７抗原的急性髓性白血病（ａｃｕｔｅｍｙｅｌｏｃｙｔｉｃｌｅｕｋｅｍｉａ，ＡＭＬ）患者的临床特征、免疫表型及细胞遗传学特征。方法：选择１９９２年８月至１９９６年９月在我院住院治疗的成人ＡＭＬ患者９９例，采用间接免疫荧光法及Ｇ显带进行免疫表型及染色体核型分析，治疗采用我院常规化疗方案。结果：１２例（１２．１２％）ＡＭＬ患者表达ＣＤ７抗原，其中１１例（１１／１２）同时表达ＨＬＡＤＲ；受检的８例患者（１００％）皆同时表达ＣＤ３８；骨髓染色体分析，３例异常，可见－７，１７ｐ＋，９ｑ＋，５ｑ－，＋８及ｔ（８；２１）。此外，肝肿大者６例（６／１２），完全缓解（ｃｏｍｐｌｅｔｅｒｅｍｉｓｓｉｏｎ，ＣＲ）者５例（５／１２），与ＣＤ７－组比较差异有统计学意义。结论：ＣＤ７＋ＡＭＬ多同时表达ＨＬＡＤＲ、ＣＤ３８，染色体核型无特征性异常，肝肿大发生率高，ＣＲ率低，预后不良
Objective: To investigate the clinical features, immunophenotype and cytogenetic features of acute myeloid leukemia (AML) patients expressing CD7 antigen. METHODS: A total of 99 adult AML patients hospitalized in our hospital from August 1992 to September 1996 were selected. Immunophenotyping and karyotype analysis were performed using indirect immunofluorescence and G-banding. The treatment was performed using conventional chemotherapy in our hospital. . RESULTS: Twelve patients (12.12%) with AML expressed CD7 antigen, 11 (11/12) of them simultaneously expressed HLA-DR; 8 patients (100%) examined expressed CD38 at the same time; bone marrow chromosome analysis, 3 Abnormalities were found -7,17p+,9q+,5q-,+8 and t(8;21). In addition, 6 cases (6/12) were hepatomegaly and 5 cases (5/12) were complete remission (CR). There was a significant difference compared with CD7-group. Conclusion:CD7+AML expresses HLA-DR and CD38 at the same time. There is no characteristic abnormality in karyotype. The incidence of hepatomegaly is high, CR rate is low, and the prognosis is poor.