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舌咽、迷走神经向三叉神经脊束间质核的投射纤维除传递非伤害性内脏信息者外是否也含内脏伤害性传入？尚未见报道。本文综合应用：（1）福尔马林刺激舌咽、迷走神经支配的一些内脏诱导FOS蛋白表达；（2）抽除外周神经节观察三叉神经脊束间质核内一些与伤害性信息传递有关的神经递质的变化；（3）运用荧光金逆行追踪与免疫组化相结合的双重反应等方法，对大鼠投射至三叉神经脊束间质核的舌烟、迷走神经初级传入纤维中是否含传递伤害性刺激信息的成分进行了研究。结果证明：(1)2％福尔马林刺激大鼠软腭、咽、食道和胃后，三叉神经脊束间质核内有大量FOS阳性神经元表达，这些阳性神经元与舌咽、迷走神经初级传入分布区基本一致。（2）抽除一侧舌咽、谈走神经报及其神经节后，术侧三叉神经脊束间质核内SP、CGRP等和痛传递有关的神经肽及BSI-B_4阳性终末与对侧比较明显减少。（3）荧光金微量注入三叉神经脊束间质核后，在舌咽、迷走神经节的下节内发现被荧光金逆标的细胞中分别有10％和12％呈SP、CGRP阳性，此两种双重阳性细胞分别占SP、CGRP阳性细胞的33．3%和278％。以上结果提示，三叉神经脊束间质核接受舌咽、迷走神经的传入纤维中有一部分传递内脏伤害性信息。
Glossopharyngeal, vagal nerve to the trigeminal nerve fibers in the projection of the stromal nucleus in addition to non-invasive visceral information also contains visceral nociceptive afferent? Not yet reported. This article is a comprehensive application of: (1) formalin stimulation of glossopharyngeal and vagal innervate some of the visceral induction of FOS protein expression; (2) removal of peripheral ganglia observed in the trigeminal nerve spina bifida and some of the nociceptive information related to nociceptive transmission Neurotransmitter changes; (3) the use of fluorescent gold retrograde tracing and immunohistochemistry combined with dual reaction and other methods, the rat projected to the trigeminal nerve bundle interstitial nucleus of the tongue and the vagus nerve primary afferent fibers whether Components that convey nociceptive information were studied. The results showed that: (1) A large number of FOS-positive neurons were expressed in the interspinous nucleus of the trigeminal nerve after stimulation with 2% formalin in the soft palate, pharynx, esophagus and stomach. These positive neurons were associated with the glossopharyngeal and vagal primary Inbound distribution basically the same. (2) remove the glossopharyngeal side, to talk about the nerve newspaper and its ganglion, the side of the trigeminal nerve spine in the SP, CGRP and other pain-related neuropeptide and BSI-B_4-positive terminal and Side significantly reduced. (3) Fluorescent gold microinjection into the trigeminal nerve bundle interstitial nucleus, 10% and 12% were found in the glossopharyngeal, vagal ganglion cells in the next section were fluorescent gold SP, CGRP positive, the two Double positive cells accounted for 33.3% and 278% of SP and CGRP positive cells, respectively. The above results suggest that part of the afferent fibers of the glossopharyngeal and vagal nerves of the trigeminal nerve bundle transmit visceral nociceptive information.