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1987年12月～1997年1月间该科收治弥漫增殖型（Ⅳ型）狼疮性肾炎（LN）并急性肾功能衰竭（ARF）患者23例，与随机抽取的20例同期住院的Ⅳ型LN肾功能正常的病人就临床特点、病理学参数、疗效及转归进行了对比分析。采用糖皮质激素和（或）环磷酰胺等治疗。肾活检病理学参数，活动性指数ARF组显著高于非ARF组，而二组慢性指数无显著差异；临床治疗效果二组总有效率无显著差异。提示Ⅳ型LN并ARF予强化治疗可顿挫病情，改善预后。ARF组治疗无效的8例中，除2例死亡外，6例活动性指数和慢性指数均较高，短期内转为尿毒症。提示活动性指数和慢性指数均高时预示转归不良。
Between December 1987 and January 1997, 23 patients with diffuse proliferative (type Ⅳ) lupus nephritis (LN) and acute renal failure (ARF) were enrolled in this study. Twenty patients with type Ⅳ LN Patients with normal renal function on clinical features, pathological parameters, efficacy and outcome were compared. Glucocorticoid and (or) cyclophosphamide and other treatment. Renal biopsy pathological parameters, activity index ARF group was significantly higher than non-ARF group, while the two groups no significant difference in chronic index; clinical effect of the two groups no significant difference in total effective rate. Prompt type Ⅳ LN and ARF to strengthen the treatment can frustrate the disease, improve the prognosis. ARF group of 8 cases of ineffective treatment, in addition to two cases of death, 6 cases of activity index and chronic index were higher in the short term into uremia. Prompt activity index and chronic index are high indicates poor outcome.