大鼠鼻腔吸收吲哚美辛(英文)

• 作 者: 黄志力 鹿兒岛正豊 香川榮一郎 岛田英世
• 机 构: 北里大学药学部临床药理学教室,北里大学药学部临床药理学教室,北里大学药学部临床药理学教室,北里大学药学部临床药理学教室 东京 108 日本国,东京 108 日本国,东京 108 日本国,东京 108
• 出 处: Acta Pharmacologica Sinica
• 发表日期: 1995年02期
• 关键词: 吲哚美辛 鼻腔给药 药物动力学 大鼠 鼻内给药 静脉给药 峰值浓度 高效液相色谱法 峰浓度 峰时间

目的,研究吲哚美辛经大鼠鼻腔给药的可行性,方法:用高效液相色谱仪测定血浆中吲哚美辛的药浓变化,比较大鼠吲哚美辛3 mg·kg~(-1)水溶液经口服、静脉与鼻腔给药的吸收特点.结果:鼻腔给药达峰时间为0.08 h,几乎接近于静脉给药;峰浓度为20-O mg·L~(-1),是口服给药的2.4倍.吲哚美辛水溶液鼻腔给药达峰迅速,峰值浓度高,吸收好.结论:低剂量吲哚美辛经鼻腔给药为一合理,可望替代口服的给药方式.

Objective To study the feasibility of indometacin nasal administration in rats by HPLC: Determination of indometacin drug concentration in plasma by high performance liquid chromatography, compared indomethacin 3 mg · kg ~ ( -1) aqueous solution by oral, intravenous and nasal administration.Results: The nasal delivery peak time was 0.08 h, almost close to the intravenous administration; peak concentration of 20-O mg · L -1, Is 2.4 times that of oral administration.Impromic sodium aqueous solution peaked nasally, the peak concentration is high, absorbed well.Conclusion: The low dose of indomethacin nasal delivery as a reasonable, is expected to replace the oral administration the way.