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目的观察沙利度胺治疗由于发育不良所导致的消化道出血的治疗效果,探究沙利度胺的应用机制。方法选取在宜黄县人民医院诊治的5例由发育不良所导致的消化道出血患者,对这5例患者采用沙利度胺进行为期4个月的疗程治疗,药物的剂量为平均每天每人100 mg,观察和对比患者在采用沙利度胺治疗前和治疗过程中患者消化道出血的次数、血红蛋白含量的变化。结果 4个月的沙利度胺疗程治疗后发现,与治疗前相比,患者出血次数明显减少,治疗前后出血次数比较,差异有统计学意义(P<0.05);同时在治疗后患者的血红蛋白含量有明显的增加,血红蛋白含量治疗前后比较,差异有统计学意义(P<0.05)。结论沙利度胺在由发育不良所致的消化道出血治疗中具有明显的治疗效果,值得在临床中推广。
Objective To observe the effect of thalidomide on the treatment of gastrointestinal bleeding caused by dysplasia and to explore the mechanism of application of thalidomide. Methods A total of 5 patients with gastrointestinal bleeding caused by dysplasia were selected and treated in Yihuang People’s Hospital. The 5 patients were treated with thalidomide for 4 months. The average daily dose of the drug was 100 mg. The number of patients with gastrointestinal bleeding and hemoglobin before and during the treatment with thalidomide were observed and compared. Results After 4 months of thalidomide treatment, the number of bleeding and the number of bleeding before and after treatment were significantly lower than those before treatment (P <0.05). At the same time, the hemoglobin Content significantly increased, hemoglobin content before and after treatment, the difference was statistically significant (P <0.05). Conclusions Thalidomide has obvious curative effect in the treatment of gastrointestinal bleeding caused by dysplasia, which is worth to be popularized in clinic.