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目的:研究喘息婴幼儿潮气肺功能和呼出气一氧化氮(FeNO)的变化，着重探讨过敏体质在其中的潜在作用。方法:纳入成都市妇女儿童中心医院呼吸科2018年2月至2019年1月收治的急性下呼吸道感染婴幼儿285例，回顾性分析患儿的一般资料，喘息的危险因素，喘息与潮气肺功能及FeNO的关系，并通过亚组分析探究过敏因素在其中的作用。结果:Logistic回归分析发现男性(n χ2＝13.071，n P<0.001)及过敏体质(n χ2＝8.889，n P＝0.003)是喘息的危险因素。在纳入的总体人群中，喘息者较非喘息者达峰时间比(TPTEF/TE)及达峰容积比(VPEF/VE)降低，FeNO增高，差异均有统计学意义(n P值均<0.05)；在喘息患儿中，过敏体质不影响潮气肺功能，但与FeNO增高有关(n Z＝-2.109，n P<0.05)。按过敏体质亚组分析，非过敏体质患儿喘息者较非喘息者TPTEF/TE及VPEF/VE降低，差异均有统计学意义(n P值均0.05)；按过敏原种类分组，吸入过敏原及混合过敏原阳性者较过敏原阴性者FeNO增高，差异均有统计学意义(n P值均0.05)。n 结论:喘息婴幼儿潮气肺功能受损，FeNO增高；且潮气肺功能改变不依赖过敏状态，而FeNO增高与吸入过敏原阳性有关。进一步探讨吸入过敏原亚类对喘息婴幼儿FeNO的影响可能为临床上精准治疗提供理论依据。“,”Objective:To explore the variation of tidal breathing lung function and fractional exhaled nitric oxide (FeNO) on wheezing infants, especially when taking the role of atopy into consideration.Methods:A total of 285 inpatient infants who were diagnosed with acute lower respiratory tract infections from February 2018 to January 2019 were enrolled in Chengdu Women′s & Children′s Central Hospital.And a retrospective analysis of the general data of the cases, the risk factors of wheeze, and the relationships between wheeze and lung function/FeNO were conducted.In addition, subgroup analysis was used to explore the potential effects of atopy in the relationships.Results:Logistic regression analysis revealed that male (n χ2=13.071, n P<0.001) and atopy (n χ2=8.889, n P=0.003) were the main risk factors affecting wheeze.Among the total cases included, infants with wheeze had lower time to peak tidal expiratory flow as a proportion of expiratory time (TPTEF/TE) and lower volume to peak expiratory flow as a proportion of exhaled volume (VPEF/VE), but higher FeNO than that of infants without wheeze (all n P<0.05). As for infants with wheeze, atopy didn′t affect tidal breathing lung function parameters, but it was related to FeNO increase (n P<0.05). Subgroup analysis of atopy revealed that infants with wheeze had lower TPTEF/TE and VPEF/VE (bothn P0.05) among non atopic patients.According to allergen categories, it was found that FeNO was higher in the infants with inhaled and mixed allergens positive than that of those with allergens negative (n P0.05).n Conclusions:As for infants with wheeze, the tidal breathing lung function reduces, while FeNO increases.The influence of wheeze on lung function does not depend on atopy.However, the effect of wheeze on FeNO is related to inhaled allergen spositive.Further investigation to the effects of subgroup inhaled allergens on wheeze and FeNO may provide a theoretical foundation for accurate clinical treatment.