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目的：研究不同剂量尼莫地平辅助治疗癫痫的疗效。方法：９２例癫痫病人，男性５４例，女性３８例，年龄（２９± ｓ ７） ａ， １８～５７ ａ，在卡马西平治疗至少３ｍｏ后，随机分为２组添加尼莫地平治疗。大剂量组（４６例）口服尼莫地平 ６０ ｍｇ， ｑ ６ ｈ；小剂量组（４６例）口服尼莫地平 ２０ ｍｇ， ｑ ８ ｈ，共 ３ ｍｏ。结果：大剂量组每人癫痫发作次数明显减少［治疗前（ １７ ± ７）次；治疗后（８±６）次， Ｐ＜ ０． ０１］，总有效率４６％。小剂量组每人癫痫发作次数明显减少［治疗前（１８±８）次；治疗后（６±６）次，Ｐ＜０．０１］，总有效率１７％。大剂量组与小剂量组每月发作次数比较差异有非常显著意义（ Ｐ＜ ０． ０１）。结论：尼莫地平辅助治疗癫痫有效，口服 ６０ ｍｇ， ｑ ６ ｈ疗效较好。
Objective: To study the effect of different doses of nimodipine in the treatment of epilepsy. Methods: A total of 92 patients with epilepsy were enrolled in this study. There were 54 males and 38 females, aged 29 ± s 7 and 18 ~ 57 years. After carbamazepine treatment for at least 3 months, they were randomly divided into 2 groups treated with nimodipine. The nimodipine 60 mg, q 6 h was given to the high-dose group (n = 46). Nimodipine 20 mg q q was given orally for 3 months in the low-dose group (n = 46). Results: The number of epileptic seizures decreased significantly in high-dose group (17 ± 7) before treatment (8 ± 6), P <0. 01], the total efficiency of 46%. The number of epileptic seizures in the low-dose group decreased significantly (18 ± 8) before treatment (6 ± 6), P <0.01], and the total effective rate was 17%. High-dose group and low-dose group the number of monthly sepsis was significantly different (P <0.01). Conclusion: Nimodipine is effective in treating epilepsy. Oral administration of 60 mg q 6 h has a good effect.