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缺血心肌恢复再灌注后,常伴发更严重的损伤,即“再灌注损伤”.近年来这一问题日益受到重视,研究也逐步深入.尽管如此,仍有不少临床工作者对其发生在临床上的危害及严重性表示怀疑,本文拟就再灌注损伤的确实性、实验与临床表现的差异及原因作一综述.1 再灌注损伤特征性表现一般认为,冠状动脉(冠脉)闭塞短于5分钟,心肌处于可逆性损伤,恢复再灌注,缺血心肌可较快地完全恢复正常.而冠脉阻塞在5～20分钟内恢复再灌注,缺血心肌的形态、结构、代谢变化及功能状态常需数小时或数天才能恢复正常,出现延迟恢复的现象,即“心肌顿抑”(stunned myocardium).若冠脉
After the reperfusion of ischemic myocardium, it often accompanied by more serious injury, namely “reperfusion injury.” In recent years, this issue has been given more attention, the research has gradually deepened.However, there are still many clinical workers on its occurrence This paper is to review the accuracy of reperfusion injury, the differences between experimental and clinical manifestations, and the reasons for this. (1) The characteristic manifestation of reperfusion injury is generally believed that the coronary artery (coronary artery) occlusion In less than 5 minutes, the myocardium is in a reversible injury, recovering and reperfusion, and the ischemic myocardium can return to normal quickly, while the coronary occlusion resumes reperfusion within 5 to 20 minutes. The morphology, structure and metabolic changes of ischemic myocardium And functional status often take hours or days to return to normal, the phenomenon of delayed recovery, “stunned myocardium.” If the coronary artery